Naslov
MAGE-A1, MAGE-A3 AND NY-ESO-1 IN SQUAMOUS CELL CARCINOMA OF THE PENIS

Autori
Hudolin, Tvrtko ; Juretić, A ; Pasini, J ; Dimanovski, J ; Krušlin, Božo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Acta clinica croatica / Kusić Z - Zagreb : Birotisak, 2005, 233-233

Skup
16th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 03.06.2005. - 04.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Squamous cell carcinoma; Penis

Sažetak
AIM: To investigate immunohistochemical expression of MAGE-A and NY-ESO-1/LAGE-1, cancer testis antigens in penile carcinoma tissue. METHODS: 30 penile carcinoma samples from patients undergoing penile amputation at the Urology Clinic at the Zagreb Clinical Hospital Center and Clinical Hospital Sestre milosrdnice from 1997 to 2004 were investigated in this study. Three monoclonal antibodies were used for immunohistochemical staining: 77B for MAGE-A1, 57B for multi-MAGE-A and D8.38 for NY-ESO-1 expression. RESULTS: The mean patient age was 64.7 years old (range 41 to 92). Expression of MAGE-A1 was observed in 13% of carcinoma samples, whereas both multi-MAGE-A and NY-ESO-1 stained 97% of samples. Immunohistochemical staining was only detectable in the cytoplasm. A significant heterogeneity could be observed within a same tissue sample where areas with strong positivities coexisted with cancer testis antigens negative areas. Cancer testis antigens expression was not significantly correlated with the tumor grade. CONCLUSION: This study documents for the first time the expression of CTA in penis cancers. Further research is warranted with potential implications regarding both diagnosis and therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA