Naslov
FIBROMUSCULAR DYSPLASIA OF RENAL ARTERIES IN NON- TUMOROUS SURGICAL SPECIMENS

Autori
Tomić, Karla ; Tomas, Davor ; Ulamec, Monika ; Leniček, Tanja ; Tomašković, Igor ; Kos, Marina ; Krušlin, Božo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Acta clinica croatica / Kusić Z - Zagreb : Birotisak, 2005

Skup
16th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 03.06.2005. - 04.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Fibromuscular dysplasia; Renal arteries

Sažetak
INTRODUCTION AND AIM: Arterial fibromuscular dysplasia (FMD) is a condition that most frequently involves renal arteries, and is bilateral in nearly half of the cases. It is more frequent on the right side (3:1), with female predominance. FMD of the renal arteries usually involves distal parts of the artery and its branches. The aim of this study was to analyze renal arteries in patients who underwent nephrectomy due to non-tumorous conditions of the kidney. MATERIALS AND METHODS: We analyzed a consecutive series of 30 patients (m:f=14:16) who underwent nephrectomy in the year 2003, and whose histopathologic examination resulted in diagnosis of a benign condition. Eight patients were excluded from the study because specimens of renal arteries were not found. The median age of the patients (m:f=8:14) was 59.4 years (range 39-78 y). The patients were divided into the group showing FMD (group I) and those that showed no pathological changes of the renal arteries (group II). Specimens were routinely fixed, embedded in paraffin, cut at 5 μ m, stained with hematoxylin and eosin, and examined by light microscopy. RESULTS: FMD of the renal arteries (group I) was found in 10/22 patients (m:f=4:6) , with median age of 64 y (range 39-79 y). Renal arteries in 12/22 patients (group II) (m:f=4:8), with median age of 61 y (range 43-70 y), showed no changes. Histopathologic analysis of the renal tissue showed chronic pyelonephritis in all 10 patients from the group I, while 7 patients from the group II had the same diagnosis. Other diagnoses in the group II were renal calculi, cystic renal disease, hydronephrosis and renal hypoplasia. CONCLUSION: In other studies, the incidence of FMD in renal arteries, found at autopsy was about 1%, but we did not find any data about the incidence in vivo. In this study, fibromuscular dysplasia of the renal arteries was observed in a significant proportion of patients who underwent nephrectomy due to non-tumorous diseases. The significance of this finding should be further analyzed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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