Naslov
Dopamine conjugate with styrene-maleic anhydride copolymer

Autori
Kalčić, Igor ; Zorc, Branka ; Butula, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Pharmaceutical Sciences (EUFEPS), Elsevier / Junginger, Hans E. ; Mulder, Gerard J. - Edinburgh : European Federation for Pharmaceutical Sciences, 1996

Skup
Third European Congress of Pharmaceutical Sciences

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 09.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
dopamine; polymer-drug conjugate; kinetics

Sažetak
Dopamine (3,4-dihydroxyphenethylamine, DOP) was covalently bond to styrene.maleic anhydride copolymer (SMA) in order to prepare polymeric prodrug SMA-DOP as potentially form of dopamine. The coupling reaction was run under nitrogen atmosphere in dry N, N-dimethylformamide in the presence of sodium dithionite. The remainig anhydride rings were opened with water. Shema The resulting conjugate contained 42.8 % of drug. Release of dopamine from SMA-DOP conjugate was studied in vitro and the following rate constants were obtained: k = 2.27 x 10-3 min-1 for pH = 7.4 and k = 7.98 x 10-2 min-1 for pH = 9.2.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA