Naslov
Lipid Lowering Treatment In Secondary Stroke Prevention

Autori
Lisak, Marijana ; Trkanjec, Zlatko ; Demarin, Vida

Izvornik
Acta clinica Croatica (0353-9466) 44 (2005), 2; 131-137

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
secondary prevention of stroke; Lipid lowering treatment; Hypercholesterolemia; Statins
(secondary prevention of stroke; lipid lowering treatment; hypercholesterolemia; statins)

Sažetak
Secondary preventive measures such as measur Lipid Lowering Treatment In Secondary Stroke Prevention ing serum cholesterol levels and treatment of hypercholesterolemia with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors-statins are not used enough in patients with acute stroke or transient ischemic attack, although statins offer potential benefits for reducing the incidence and improving the prognosis of stroke. Statins could have additional effects besides lipid lowering such as improvement of endothelial-dependent flow-mediated vasodilatation, modulating the inflammatory response, decreasing clot formation, and decreasing the adherence of platelets to the ruptured plaque thus stabilizing the atherosclerotic plaque. Other antiatherosclerotic properties of statins include reducing of accumulation of inflammatory cells in atherosclerotic plaques, inhibiting vascular smooth muscle cell proliferation, inhibiting platelet function, and improving of vascular endothelial function. Randomized clinical trials and evidence base medicine support the role of statin therapy in preventing ischemic stroke in patient subgroups at risk of cerebrovascular disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA