Naslov
Effect of hypolipidemic drugs on cholinesterase activity in the rat

Autori
Kunec-Vajić, Estera ; Bernat, Nada ; Muačević- Katanec, Diana

Izvornik
General pharmacology (0306-3623) 23 (1992); 217-219

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hypolipidemic agents ; phenofibrate ; probucol ; colestipol ; nicotinic acid ; plasma and liver cholinesterase

Sažetak
1. The effect of four hypolipidemic agents with different mechanisms of action (fenofibrate, probucol, colestipol and nicotinic acid) on plasma and liver cholinesterase has been studied. 2. Liver weight and liver weight/body weight ratio increased only after treatment with fenofibrate. 3. Plasma and liver cholinesterase activity increased markedly after fenofibrate, a strong peroxisome proliferator, and slightly after nicotinic acid, a weak peroxisome proliferator. 4. The data obtained suggest that increased cholinesterase activity is due to increased rate of fatty acid oxidation caused by peroxisome proliferators.

Izvorni jezik
Engleski

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