Naslov
Ischemic childhood stroke and lipoprotein (a)

Autori
Lenicek Krleza, Jasna ; Zrinski Topic, Renata ; Rogic, Dunja ; Coen Herak, Desiree ; Đuranović, Vlasta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Thrombosis and Haemostasis / Mannucci, Pier Mannuccio - Malden (MA) : Wiley-Blackwell, 2005

Skup
XX Congres of the International Society on Thrombosis and Haemostasis

Mjesto i datum
Sydney, Australija, 06.08.2005. - 12.08.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Lp(a); ischemic childhood stroke

Sažetak
Ischemic stroke in children have incidence of 2, 5 – 3, 0 per 100 000 per year. Approximately, one third of cases no obvious cause. The association between childhood stroke and thrombophilia has been debated. Elevated lipoprotein (a), Lp(a), has been identified as risk factor for ischemic stroke in young adults, but only preliminary data are a available on its role as a risk factor for ischemic stroke in infants and children. We studied the prevalence of elevated Lp(a) in 47 children (30 males and 17 females, age range 0 -18 years, average 7, 8 years) with ischemic stroke compared with 42 control subjects (children in 2 – 18 years old, average 10, 3 years). Diagnoses of stroke were confirmed by neurological examination including computed tomography and magnetic resonance. Concentrations Lp(a) in patient with stroke had median 0, 13 (range 0, 13- 1, 92) and control subjects median 0, 125 (range 0, 01-0, 81). Lp(a) values higher above 0, 30 g/L we found in 15 patient (31, 9%) compared with control subjects (10 of 42 ; 23, 8%). The prevalence of elevated Lp(a) was higher among pediatric stroke patient than among control subjects, but the difference was not statistically significant (p=0, 8578). In conclusion, despite a low number of children in each group, we believe that Lp(a) is one of important thrombophilia marker possible in stroke with no cause or underlying disorders detected.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

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