Naslov
Level of Lipid Peroxidation and Total Antioxidant Status in Hyper- and Hypothyroid Patients before and after Treatment

Autori
Žmire, Josip ; Vučić Lovrenčić, Marijana ; Sokolić, Lea ; Kljajić, Kristina ; Čolak, Božo ; Ročić, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7^th European Congress of Endocrinology, ECE 2005. Abstract book / - Gothenburg, 2005

Skup
7^th European Congress of Endocrinology, ECE 2005.

Mjesto i datum
Göteborg, Švedska, 03.09.2005. - 07.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
total antioxidant status (TAS); lipid peroxidation; hypothyroidism; hyperthyroidism

Sažetak
We assessed levels of total antioxidant status (TAS) and malonyldialdehyde (MDA) as indicator of lipid peroxidation in 68 hyperthyroid (H) (62 female and 6 male, aged 22-84 yrs) and 52 hypothyroid (h) (51 female and 1 male, aged 23-76 yrs) patients before and after the treatment in comparison with 47 age and gender-matched healthy controls. TAS was measured with colorimetric method using ABTS chromogen and standardised via synthetic vitamin E analogue (Trolox). The level of lipid peroxidation was assessed by measuring MDA levels in erythrocytes using colorimetric TBA method. The results are expressed as nmol MDA/ml erythrocyte (E). Hypothyroid patients had slightly higher levels of TAS before treatment (1, 38 &plusmn ; 0, 12 mmol/l) than hyperthyroid (1, 34 &plusmn ; 0, 15 ; N.S.) ones and this level did not change after reaching euthyroid state (Eu) (1.38 &plusmn ; 0, 14 mmol). In H group TAS levels were higher (but not significantly) before treatment than afterwards (1, 34 &plusmn ; 0, 15 vs 1, 32 &plusmn ; 0, 11 ; N.S.). Both H and h groups had significantly lower TAS values than controls (1, 54 &plusmn ; 0, 08 mmol/l ; p<0.05). Posttreatment MDA values in both hyperthyroid (0, 87 &plusmn ; 0, 34 nmol/ml E) and hypothyroid (0, 87 &plusmn ; 0, 45) groups were the same and showed slight but significant decrease vs initial hyperthyroid (1, 02 &plusmn ; 0, 37) and hypothyroid sattus (1, 06 &plusmn ; 0, 45)(p<0.05). h MDA values (1, 06 &plusmn ; 0, 45) were slightly but insignificantly higher than H ones (1, 02 &plusmn ; 0, 37). All patient MDA levels had significantly lower values than control euthyroid ones (1, 39 &plusmn ; 0, 36 nmol/ml E ; p<0.05). We conclude that hyperthyroidism has greater impact on antioxidative status of the body than hypothyroidism. All posttreatment results still decline from normal values from control group.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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