Pregled bibliografske jedinice broj: 209864
Is smoking habit masking airway minimal persistent inflammation (MPI) present in sensitised nonasthmatics?
Is smoking habit masking airway minimal persistent inflammation (MPI) present in sensitised nonasthmatics? // Toxicology Letters / Dekant, Wolfgang (ur.).
Amsterdam: Elsevier, 2005. (predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 209864 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Is smoking habit masking airway minimal persistent inflammation (MPI) present in sensitised nonasthmatics?
Autori
Mirić, Mirjana ; Maloča, Ivana ; Macan, Jelena ; Plavec, Davor
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Toxicology Letters
/ Dekant, Wolfgang - Amsterdam : Elsevier, 2005
Skup
42nd Congress of the European Societies of Toxicology, Eurotox 2005
Mjesto i datum
Kraków, Poljska, 11.09.2005. - 14.09.2005
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
atopy; house-dust mite; Dermatophagoides pteronyssinus; skin prick test; nonspecific bronchial reactivity; total IgE; specific IgE; minimal persistent inflammation
Sažetak
To examine the relationship and confounding factors of sensitization to house-dust mites with nonspecific bronchial reactivity (NBR) in nonasthmatic asymptomatic subjects. Retrospective study (2001-2003) included all subjects that underwent medical history, physical examination, spirometry, nonspecific bronchoprovocation, skin prick test to Dermatophagoides pteronyssinus (DP) and measurements of total and specific IgE. There were 234 (114 women ; 146 smokers) subjects included into analysis. The mean (SD) age of the subjects was 29.4 (6.4) years. None of them had asthma. All subjects had lung function parameters inside normal range. 69 subjects (29.5%) had clinically relevant positive skin prick test (≥ 3 mm). The number of subjects who had specific IgE to DP>0 kU/L was 98 (41.9%). When two subgroups (specific IgE 0 or >0 kU/L) were compared, the second one had all lung function parameters significantly lower with NBR significantly higher (P<0.05 for all). Multiple regression analysis in the second subgroup revealed significant correlation between NBR and specific IgE level (r=0.52, P<0.001). Smoking habit was a significant independent predictor of NBR (OR, 0.16 ; 95% CI, 0.031-0.828 ; P=0.0256). It seems that smoking habit can mask the existence of MPI present in sensitized individuals without clinical expression of asthma. Further studies are needed to completely elucidate the underlying pathophysiologic mechanisms.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
0022004
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
