Naslov
Cognitive function improving in children with epilepsy switched from valproate to lamotrigine.

Autori
Prpić, Igor ; Vlašić-Cicvarić, Inge ; Paučić-Kirinčić, Ela ; Korotaj, Zrinka ; Škarpa-Prpić, Ingrid

Izvornik
Epilepsia (Copenhagen) (0013-9580) 43 (2002), Suppl. 8;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
epilepsy; cognitive function; antiepileptic drugs

Sažetak
PURPOSE: Anecdotal reports and rare studies in children revealed that lamotrigine (LTG) may have positive effect on cognitive functions. Therefore cognitive abilities in children with idiopathic generalised epilepsy (IGE) during treatment with valproate (VPA) and after they were switched to LTG were compared. METHODES: Fourteen children, 8 girls and 6 boys (M=13, 5 age ; SD 1.5) with newly diagnosed IGE (ILAE classification) were prospectively analysed. VPA was first AED in all children but due to its side effects children were switched to LTG mono-therapy. Average duration of VPA treatment was 24, 2 months. Average duration of LTG treatment was 10, 3 months. All children were seizure free on both treatments. Psychological assessment was performed during the VPA treatment and at least 6 months after the initiation of LTG (test-retest). Intellectual and cognitive abilities were evaluated by Perceptual Intelligence Test – Raven (PIT), the Bender-Gestalt Test (BGT) and Wechsler Intelligence Scales for Children (WISC). The Kaufman factors: Verbal Comprehension (VC), Perceptual Organisation (PO) and Freedom from Distractibility (FD) were calculated and compared (t-test, 2-sided) for test – retest examination. VC and PO are comparable to the WISC verbal and performance IQ and FD is an additional scale and reflects attention, concentration, memory and the ability of processing and sequencing. RESULTS: Mean Kaufman FD factor was 93, 6 (SD=16, 1) on children taking VPA and 102, 3 (SD=16, 4) on children taking LTG which was statistically significant difference (p=0.0003). There was not found significant differences comparing scores on VC, PO, PIT and BGT. CONCLUSION: All children after switching from VPA to LTG improved in attention, concentration, memory and the ability of sequencing and processing. Our results revealed that LTG have less impairment on specific cognitive functions in children with idiopathic generalised epilepsy. These data needs to be validated on greater number of children as well as in different types of epilepsy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
5th European Congress on Epileptology, October 6-10, 2002, Madrid, Spain.

POVEZANOST RADA