Pregled bibliografske jedinice broj: 207170
Activation of a p53-dependent checkpoint response by inactivation of one S6 allele during gastrulation
Activation of a p53-dependent checkpoint response by inactivation of one S6 allele during gastrulation // Četvrti hrvatski kongres farmakologije s međunarodnim učešćem
Split, Hrvatska, 2004. (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 207170 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Activation of a p53-dependent checkpoint response by inactivation of one S6 allele during gastrulation
Autori
Volarević, Siniša
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Četvrti hrvatski kongres farmakologije s međunarodnim učešćem
Mjesto i datum
Split, Hrvatska, 14.09.2004. - 18.09.2004
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
S6 ribosomal protein; ribosome biogenesis; p53 checkpoint
Sažetak
Ribosome biogenesis is required for the large increase in the rate of protein synthesis that occurs during cell growth and proliferation. Even though ribosome biogenesis is intense during mouse oogenesis, this pool of ribosomes is not sufficient to support an enormous growth of the embryo during early embryogenesis. Therefore, the synthesis of new ribosomes is activated at the six- to eight-cell stage embryo. An error in ribosome biogenesis could have a deleterious consequence on oogenesis and embryonic development through impaired protein translation. Additionally, molecular mechanisms that sense the fidelity of ribosome biogenesis may exist. To gain insight into these processes we induced a defect in ribosome biogenesis by conditionally deleting one allele of the 40S ribosomal protein S6 gene in the growing mouse oocytes and generated S6-heterozygous embryos by appropriate breeding.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
