Pregled bibliografske jedinice broj: 207136
The response of mammalian cells to a defect in ribosome biogenesis
The response of mammalian cells to a defect in ribosome biogenesis // Kongres hrvatskog genetičkog društva
Supetar, Hrvatska, 2005. (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 207136 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The response of mammalian cells to a defect in ribosome biogenesis
Autori
Volarević, Siniša
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Kongres hrvatskog genetičkog društva
Mjesto i datum
Supetar, Hrvatska, 24.09.2005. - 27.09.2005
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
cell growth; cell division; ribosome biogenesis
Sažetak
Ribosome biogenesis is required for the large increase in the rate of protein synthesis that occurs during cell growth and proliferation. Even though ribosome biogenesis is intense during mouse oogenesis, this pool of ribosomes is not sufficient to support an enormous growth of the embryo during early embryogenesis. An error in ribosome biogenesis could have a deleterious consequence on oogenesis and embryonic development through impaired protein translation. Additionally, molecular mechanisms that sense the fidelity of ribosome biogenesis may exist. To gain insight into these processes we induced a defect in ribosome biogenesis by conditionally deleting one allele of the 40S ribosomal protein S6 gene in the growing mouse oocytes and generated S6-heterozygous embryos by appropriate breeding.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
