Pregled bibliografske jedinice broj: 207111
Risk factors for central nervous complications (stroke and TIA) in patients with infective endocarditis (IE)
Risk factors for central nervous complications (stroke and TIA) in patients with infective endocarditis (IE) // 8th International Symposium on Modern Concepts and Cardiovascular Infections, Abstract Book
Charleston (SC), 2005. (poster, međunarodna recenzija, sažetak, pregledni)
CROSBI ID: 207111 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Risk factors for central nervous complications (stroke and TIA) in patients with infective endocarditis (IE)
Autori
Baršić B, Olaison L, Suter F, Rizzi M, Pappas P, Rubinstein E, Bradley S, Dickerman S, Kamarulzaman A, Abrutyn E, Fowler V, Mirò ; JM, Sexton D, Cabell C
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, pregledni
Izvornik
8th International Symposium on Modern Concepts and Cardiovascular Infections, Abstract Book
/ - Charleston (SC), 2005
Skup
8th International Symposium on Modern Concepts and Cardiovascular Infections
Mjesto i datum
Charleston (SC), Sjedinjene Američke Države, 22.05.2005. - 24.05.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
endokarditis; moždani udar
(endocarditis; stroke)
Sažetak
Background: CNS complications occur in 20 – 40 % of patients with IE but their characteristics and risk factors are seldom evaluated in prospective, multicenter studies. Aim of the study: The aim of the study was to identify risk factors for CNS complications of IE and whether ASA and coumadin/warfarin modify the incidence of CNS complications. Methods: International Collaboration on Endocarditis– Prospective Cohort Study (ICE-PCS) included 1779 cases of definite IE in 39 tertiary care referral centers with an interest in IE from 16 countries. Each center utilized a standard case report form. Patients with CNS complications were selected from the database only if stroke and/or TIA occurred during the episode of IE. Results Stroke and/or TIA occurred in 355 (19.9%) patients with IE. Stroke occurred in 300 (84.5%) (ischemic 197, hemorrhagic 71, not specified 32) and TIA in 55 (15.5%) patients. Mitral valve involvement with the presence of vegetations and embolization of vascular periphery significantly increased the risk of CNS complication compared to patients without CNS complications (62.1% vs. 49.6% ; OR=2.33, 95% CI 1.82-2.98, p<0.0001 and 38.3% vs. 24.6% ; OR=3.1, 95% CI 2.03 – 4.73, p<0.0001, respectively). Use of aspirin and/or coumadin started before the episode of IE did not increase the risk of CNS complications (OR 1.06, 95% CI 0.76 – 1.46 and 1.24, 95% CI 0.91 – 1.68 ; p>0.05 respectively). In hospital mortality was significantly higher in patients with CNS complication than in other patients (29.1% vs. 14.1%, p<0.0001). Conclusion Mitral valve endocarditis with vegeations significantly increases the risk of CNS complications. We did not find that aspirin and/or warfarin increase the risk for CNS complications. CNS complications are associated with worse outcome of patients with IE.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
