Pregled bibliografske jedinice broj: 207106
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains // Science, 260 (1993), 5107; 541-544 doi:10.1126/science.8475386 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 207106 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains
Autori
Volarević, Siniša ; Niklinska, Barbara B. ; Burns, Christopher M. ; June, Carl H. ; Weissman, Allan M. ; Ashwell, Jonathan D.
Izvornik
Science (0036-8075) 260
(1993), 5107;
541-544
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
T cell activation ; CD45 ; phosphatase
Sažetak
The CD45 protein is a transmembrane tyrosine phosphatase that is required for normal T cell receptor (TCR)-mediated signaling. A chimeric complementary DNA encoding the intracellular enzymatically active portion of murine CD45 preceded by a short amino-terminal sequence from p60c-src was transfected into CD45- T cells. Expression of this chimeric protein corrected most of the TCR signaling abnormalities observed in the absence of CD45, including TCR-mediated enhancement of tyrosine kinase activity and Ca2+ flux. Thus, the enzymatically active intracellular portion of CD45 is sufficient to allow TCR transmembrane signaling.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
