Naslov
Toxic effects of Ustilago maydis and fumonisin B1 in Fischer rats

Autori
Pepeljnjak, Stjepan ; Petrik, Jozsef ; Šegvić Klarić, Maja

Izvornik
Acta Phramaceutica (1330-0075) 55 (2005); 339-348

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ustilago maydis; fumonisin B1; neurotoxicity; cytotoxicity

Sažetak
The toxicity of Ustilago maydis and possible synergism with fumonisin B1 (FB1) were studied in Fischer rats by evaluating pathological changes and biochemical parameters in blood serum (LDH, ALT, GGT, ChE) and tissue homogenate of brain and liver (AChE, ChE, GGT, ALP). One experimental group (US) consumed diet with 70% of U. maydis galls and the other group (US+FB1) was fed with pellets containing 70% of U. maydis galls and 1 mg of FB1 per kg of diet during 17 days. During the trial experimental animals were more excited showing hyperactivity. Body weight gains were slightly increased in both groups compared to control. Gross pathological changes in liver, lungs, uterus and ovaries were more pronounced in the US+FB1 than in US group. Specific catalytic activities of AChE were decreased 61% and 63% in the liver and brain homogenate of the US group (P<0.05) in relation to control, indicating neurotoxic activity of U. maydis. Also, specific catalytic concentration of AChE and ALP was significantly decreased in the liver of the US+FB1 group (P<0.05). Activity of LDH in the blood serum was increased 166% and 165% in the US+FB1 group (P<0.05) in relation to control and US group, respectively. These findings suggest that FB1 is responsible for cytotoxic effects and could increase toxicity of U. maydis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija

POVEZANOST RADA