Naslov
Chromosome aberrations - the most reliable biological indicator of exposure to low doses of ionising radiation

Autori
Rozgaj, Ružica ; Kašuba, Vilena

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Zbornik radova šestog simpozija Hrvatskog društva za zaštitu od zračenja / Garaj-Vrhovac, Verica ; Kopjar, Nevenka ; Miljanić, Saveta - Zagreb, 2005, 211-215

Skup
Šesti simpozij HRVATSKOG DRUŠTVA ZA ZAŠTITU OD ZRAČENJA

Mjesto i datum
Zagreb, Hrvatska, 18.04.2005. - 20.04.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
biološki indikatori; niske doze ionizirajućeg zračenja; kromosomske aberacije
(biological indicators; low doses of ionising radiation; chromosomal aberrations)

Sažetak
Numerous cytogenetic studies have shown an increase in lymphocyte chromosome damages in radiation workers exposed to low doses (<0.1 Gy) of ionising radiation. Chromosome aberration frequency provides the most reliable biomarker of radiation dose. Dosimertic studies in occupationally exposed populations in which cytogenetic markers were used showed contradictory results. Some showed a correlation between chromosomal aberration frequency and the absorbed dose, whereas the majority found no correlation whatsoever. Most results show that low doses produce more aberrations than expected when one extrapolates dose-response curves from higher doses. It was shown that in population exposed to low doses of ionising radiation different factors might influence aberration yield such as the induction of DNA repair enzymes, half-life of lymphocytes, age, sex, smoking and duration of exposure. The analysis of chromosome aberrations has a great importance in evaluating individual risk of ionising radiation. Periodic controls of professionals chronically exposed to low doses of ionising radiation significantly contribute to their protection.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA