Naslov
Gastrointestinalne infekcije i mukozna imunost
(Gastrointestinal infections and mucosal immunity)

Autori
Božić, Frane ; Marinculić, Albert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka 3. hrvatskog kongresa o infektivnim bolestima s međunarodnim sudjelovanjem / Jeren, Tatjana - Zagreb, 2002

Skup
3. hrvatski kongres o infektivnim bolestima s međunarodnim sudjelovanjem

Mjesto i datum
Dubrovnik, Hrvatska, 12.10.2002. - 15.10.2002

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
-

Sažetak
The immune system evolved to free the host from invading noxious pathogens ; therefore its primary objective is to fight invading pathogens growing in an uncontrolled fashion. Although the main function of the immune system is destruction, the difference between a harmful intruding pathogen and a commensal one is often subtle, so it is very important that the destructive potential of the immune system is kept under strict control. A central element of this control is tolerance. To induce tolerance the immune system uses several mechanisms, including the deletion of autoreactive T cells, the induction of anergy and active suppression of autoimmune responses. A large part of the immune system is dedicated to protection from infection at mucosal surfaces, since most pathogens gain entry to our bodies via mucosal surfaces and must be met with an effective immune response to prevent systemic disease. The mucosal immune reactions induced by a vide variety of invading pathogens can occur independent of systemic immunity, or they may act in concert. Understanding the mechanisms governing the type of induced immune response after microbial invasion of the gastrointestinal mucosa could be of crucial importance for the rational design of mucosal vaccines. In that respect, interactions between gastrointestinal pathogens, antigen-presenting cells and lymphocytes are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA