Naslov
Synthesis and Spectroscopic Evaluation of Chiral Selectors in Crial Stationary Phases

Autori
Landek, Goran ; Kontrec, Darko ; Vinković, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Chirality-2005 : Abstracts / - , 2005, 227-227

Skup
Chirality-2005

Mjesto i datum
Parma, Italija, 11.09.2005. - 14.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
chiral selector; spectroscopy

Sažetak
The enhanced demand for enantiomerically pure compounds (EPC) has led to the development of a variety of enantioselective separation methods. Like very useful one emerged liquid chromatography which use chiral stationary phases (CSPs). One of the most used CSPs named brush or Pirkle type CSPs consist of small optically active compounds covalently bound to silica gel. Generally, mechanism of chiral recognition on this type of CSPs is based on noncovalent interactions (p-p interactions, hydrogen bonding attractions and van der Waals interactions) between enantiomers of analyte and CSP. Hydrogen bond is the most often achieved by the amide group, and p-p interactions by aromatic groups with strong p-donor or p-acceptor characteristic. Recently we have developed a number of original brush-type CSPs using 1, 3-dicyano-2, 4, 5, 6-tetrachlorobenzene as a branching achiral unit. Prepared CSPs achieved in some cases the excellent enantioseparations particularly for racemates with p-acceptor characteristics. Here we present the synthesis of the set of new chiral selectors with general structure I that imitate the structure of some previously described CSPs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA