Naslov
Conversion of thyroxine to triiodothyronine and reverse triiodothyronine in human placenta and fetal membranes

Autori
Banovac, Krešimir ; Bzik, Ljubica ; Tišlarić, Dubravka ; Sekso, Mladen

Izvornik
Hormone research (0301-0163) 12 (1980); 253-259

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thyroxine conversion ; Human placenta ; Chorion

Sažetak
Conversion of thyroxine (T4) to 3, 5, 3'- triiodothyronine (T3) and reverse 3, 3', 5'- triiodothyronine (rT3) was measured in vitro in human placenta and fetal membranes. T4 (5 mcg/ml) was incubated in 0.15 mol/l phosphate buffer with tissue homogenates for 2h at 37 C, and T3 and rT3 generated were determined in ethanol extract using RIA methods. The placenta and chorion homogenates converted more T4 to T3 than to rT3 ; the placenta was more active than the chorion. In both tissues the highest converting activity was found in microsomal fractions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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