Naslov
Does dihydroergosine affect brain GABA-A recognition sites and plasma GABA levels of female and male rats

Autori
Tvrdeić, Ante ; Peričić, Danka

Izvornik
Iugoslavica physiologica et pharmacologica acta (0021-3225) 25 (1989); 147-148

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dihydroergosine ; GABA-A receptors ; 3H-muscimol ; plasma GABA levels ; rats

Sažetak
In an attempt to find out whether dihydroergosine affects rat brain GABA-A receptor sites, we measured the affinity and the number of these sites by using 3H-muscimol, a potent GABA-A receptor agonist. Besides, we measured plasma GABA levels of these animals and tested the ability of dihydroergosine to inhibit GABA-A receptor binding in vitro. Kd and Bmax values, obtained by Scatchard analysis of the data, revealed no difference between the control and dihydroergosine treated rats. Two hours after dihydroergosine administration a significant increase of plasma GABA levels was noted in females but not in males. A more detailed study on the relationship between the brain and plasma GABA levels would be desirable.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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