Naslov
Effect of GABA agonists and antagonists on the activity of the hypothalamo-pituitary-adrenal axis

Autori
Manev, Hari ; Peričić, Danka

Izvornik
Iugoslavica physiologica et pharmacologica acta (0021-3225) Suppl. 2 (1983); 129-131

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diazepam ; picrotoxin ; bicuculline ; ether stress ; plasma corticosterone ; GAD activity ; GABA ; hypothalamus

Sažetak
Immediately after exposure of rats to ether stress, the activation of hypothalamic glutamate decarboxylase (GAD) and the unchanged concentration of hypothalamic GABA were observed. This suggests that ether stress activates the hypothalamic GABA system. Both diazepam (10 mg/kg) and ether stress elevated plasma corticosterone, but the exposure of diazepam-pretreated rats to ether stress failed to produce a further rise in plasma corticosterone concentration. The administration of GABA receptor antagonists - picrotoxin and bicuculline, produced even greater increase of plasma corticosterone concentration. Corticosterone level in rats pretreated with picrotoxin and exposed to ether stress was higher than after ether stress itself, but still did not differ from that measured after the drug treatment alone.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA