Naslov
Cytokines in patients with lung cancer

Autori
Matanić, Dubravka ; Beg-Zec, Vlasta ; Stojanović, Dražen ; Mataković-Mileusnić, Nataša ; Flego, Veljko ; Milevoj-Ribić, Flavija

Izvornik
Scandinavian journal of immunology (0300-9475) 57 (2003), 2; 173-178

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer; cytokines; lung

Sažetak
Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell-mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6, releasing capacity in patients with lung carcinoma and benign lung disease. A group of 41 patients were tested for the production of TNF-alpha, IL-1beta and IL-6 in bronchoalveolar lavage (BAL) and blood. The levels of cytokines in the lung cancer patients were: (1) in BAL - IL-6, 173 +/- 85 pg/ml ; TNF-alpha, 170 +/- 116 pg/ml ; and IL-1beta, 473 +/- 440 pg/ml ; (2) in the blood - IL-6, 197 +/- 53 pg/ml ; TNF-alpha, 311 +/- 202 pg/ml ; and IL-1beta, 915 +/- 239 pg/ml. Alveolar macrophages of the patients with a lung cancer secreted significantly more cytokines, IL-6 (P = 0.0004) and IL-1beta (P = 0.0047), than alveolar macrophages of the patients with a nonmalignant lung cancer. However, significantly lower levels of cytokine production by the BAL cells were found in patients with small cell lung cancer. This production decreased further in phase IV of nonsmall cell lung cancer

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA