Naslov
The influence of some ergot drugs on the extrapyramidal and limbic GABA system

Autori
Peričić, Danka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Synaptic Constituents in Health and Disease, Proceedings of the Third Meeting of the European Society for Neurochemistry / Brzin, Miro ; Sket, Dušan ; Bachelard, Herman S. - Ljubljana : Oxford : Mladinska knjiga - Pergamon Press, 1980, 608-608

Skup
Third Meeting of the European Society for Neurochemistry

Mjesto i datum
Bled, Slovenija, 31.08.1980. - 05.09.1980

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ergot alkaloidi; GABA; GAD; GABA-T; substancija nigra; nucleus kaudatus; konvulzije
(ergot alkaloids; GABA; GAD; GABA-T; substantia nigra; caudate nucleus; convulsions)

Sažetak
Bromocriptine, dihydroergotamine and dihydroergotoxine affected the synthesis of GABA in the substantia nigra and caudate nucleus, as evidenced by an increase in the aminooxyacetic acid (AOAA, inhibitor of GABA-T) induced accumulation of GABA. Moreover, a stimulation of GAD and GABA-T was obtained with bromocriptine. When administered in combination with allylglycine (inhibitor of GAD) the ergot drugs shortened the period between allylglycine injection and the onset of convulsions. The most potent in this regard was dihydroergotoxine. This drug also lowered the ED50 for picrotoxin. The results might suggest that the ergot drugs studied inhibit the GABA mediated transmission and consequently lead to a compensatory increase of turnover in GABAergic neurons.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA