Naslov
Effect of diazepam on conflict behaviour and on plasma corticosterone levels in male and female rats

Autori
Peričić, Danka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1st Morzine Meeting ; Sex, stress and anxiety

Mjesto i datum
Morzine, Francuska, 07.01.1996. - 14.01.1996

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sex differences; diazepam; conflict behaviour; rats

Sažetak
The anxiolytic properties of diazepam and its effects on plasma corticosterone levels were compared in male and female, water deprived rats (Vogel test). The effects of diazepam on unpunished licking and comparison between the two sexes was also made. Both punished and unpunished drinking were less in females than in males. In both sexes, a clear anticonflict effect, i.e. a much greater effect on punished than on unpunished drinking, was obtained with 2 and 4 mg/kg of diazepam i.p. Plasma corticosterone levels were higher in water deprived females than in males. Following the punished and unpunished drinking procedure, plasma corticosterone levels were found to have decreased more in female than in male rats. Diazepam had similar anticonflict effects in rats of both sexes but had a greater suppressive effect on the plasma corticosterone levels in female rats. There was no correlation between the anxiolytic effects of diazepam and its effect on the plasma corticosterone levels. The results suggest sex differences in the neuroendocrine, but not in the anxiolytic, effects of diazepam.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA