Naslov
Effect of repeated stress and the treatment with ergot-alkaloid dihydroergosine on the immune response of rats

Autori
Boranić, Milivoj ; Peričić, Danka ; Šmejkal-Jagar, Lidija ; Pivac, Nela

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Interactions between brain, nervous system, behavior, endocrine and immune system

Urednik/ci
Schmoll, Hans-Joachim ; Tewes, Uwe ; Plotnikoff, Nicholas P

Izdavač
Hogrefe Publishing Group

Grad
New York (NY)

Godina
1991

Raspon stranica
60-75

ISBN
0889370664

Ključne riječi
dihydroergosine, repeated stress, immune response, plasma corticosterone, rats

Sažetak
Exposure to repeated stress (restraint, forced swimming, electroconvulsions) in the course of 4 successive days after immunization caused non-significant stimulation of the humoral immune response (PFC count) and suppressed the delayed hypersensitivity reaction (footpad swelling) of female Wistar rats. There was no correlation between alterations of the PFC immune response and corticosterone levels in plasma at the time of assay. The effects of dihydroergosine resembled those of stress. The combination of dihydroergosine and stress apparently reinforced their mutual suppressive effect on delayed hypersensitivity, but there was no synergistic increase in the PFC count.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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