Pregled bibliografske jedinice broj: 198574
The effects of antipsychotics on the GABA system
The effects of antipsychotics on the GABA system // Abstracts 4th International Symposium on Phenothiazines and Related Drugs
Zürich, 1979. str. 54-54 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 198574 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The effects of antipsychotics on the GABA system
Autori
Peričić, Danka ; Walters, Judith R.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts 4th International Symposium on Phenothiazines and Related Drugs
/ - Zürich, 1979, 54-54
Skup
4th International Symposium on Phenothiazines and Related Drugs
Mjesto i datum
Zürich, Švicarska, 09.09.1979. - 13.09.1979
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
chlorpromazine; haloperidol; clozapine; GABA; GAD; substantia nigra; caudate nucleus; cingulate cortex; pyriform cortex; rats
Sažetak
Several studies have suggested that an inhibitory striato-nigral GABAergic pathway may exert feedback control over the nigro-striatal dopamine neurons. The reciprocal relationships among these neurons have not been extensively studied. Administration of drugs (antipsychotics) which block dopamine receptors and thus prevent dopamine neurons from exerting their normal effects at postsynaptic sites affords one possible approach to this question. In the present study, the effects of three different types of antipsychotics, chlorpromazine, clozapine and haloperidol, on GABA concentration, GABA synthesis and GAD activity in various brain regions were investigated.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
