Pregled bibliografske jedinice broj: 197733
Sex differences in the response of rats to drugs affecting GABAergic transmission
Sex differences in the response of rats to drugs affecting GABAergic transmission // Life sciences, 36 (1985), 6; 541-547 doi:10.1016/0024-3205(85)90635-6 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 197733 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Sex differences in the response of rats to drugs affecting GABAergic transmission
Autori
Peričić, Danka ; Manev, Hari ; Lakić, Nela
Izvornik
Life sciences (0024-3205) 36
(1985), 6;
541-547
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
diazepam ; picrotoxin ; convulsions ; plasma corticosterone ; sex differences
Sažetak
The administration of diazepam 1.0 mg/kg decreased the level of plasma corticosterone in female but not in male Wistar rats. Picrotoxin, another drug affecting GABAergic transmission, also brought about an increase of plasma corticosterone in both sexes. However, in order to achieve a plasma corticosterone increase of similar magnitude (more than 500%) a threefold higher dose of picrotoxin had to be given to males. When the convulsive properties of picrotoxin were tested, it became evident that the dose of picrotoxin (2.5 mg/kg) which was subconvulsive in male was almost 100% convulsive in female rats. The existing sex differences in the response of rats to drugs affecting GABAergic transmission might have possible implications in the treatment of GABA system dysfunction.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Excerpta Medica
- Index Medicus
