Pregled bibliografske jedinice broj: 197695
Behavioural evidence for simultaneous dual changes of 5-HT receptor subtypes: Mode of antidepressant action?
Behavioural evidence for simultaneous dual changes of 5-HT receptor subtypes: Mode of antidepressant action? // Life sciences, 42 (1988), 25; 2593-2601 doi:10.1016/0024-3205(88)90328-1 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 197695 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Behavioural evidence for simultaneous dual changes of 5-HT receptor subtypes: Mode of antidepressant action?
Autori
Peričić, Danka ; Manev, Hari
Izvornik
Life sciences (0024-3205) 42
(1988), 25;
2593-2601
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Dihydroergosine ; Imipramine ; 5-HT mediated behaviour ; Mice ; Rats ; Guinea pigs
Sažetak
Effects of the classic antidepressant imipramine and of an imipramine-like potential antidepressant dihydroergosine were studied in mice, rats and guinea pigs using behavioural models associated with the activation of 5-HT2 and 5-HT1 receptors respectively. Both drugs given in a single dose inhibited the 5-HT2 mediated behaviour for 24 and 48 h respectively and simultaneously stimulated 5-HT1 mediated behaviour for 6 days. Blockade of 5-HT2 receptors could have reduced their inhibitory influence on 5-HT1 receptors. We propose that the interplay between the two receptor subtypes controls the serotoninergic transmission. This idea throws a new light on the mode of action of antidepressants
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Excerpta Medica
- Index Medicus
