Naslov
Effect of semiconductor GaAs laser Irradiation on pain perception in mice

Autori
Žarković, Neven ; Manev, Hari ; Peričić, Danka ; Skala, Karolj ; Jurin, Mislav ; Peršin, Ante ; Kubović, Milan

Izvornik
Lasers in surgery and medicine (0196-8092) 9 (1989); 63-66

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hot plate ; low-power laser irradiation ; pain ; morphine

Sažetak
The influence of subacute exposure (11 exposures within 16 days) of mice to the low power (GaAs) semiconductive laser-stimulated irradiation on pain perception was investigated. The pain perception was determined by the latency of foot- licking or jumping from the surface of a 53 degrees C hot plate. Repeated hot-plate testing resulted in shortening of latencies in both sham- and laser-irradiated mice. Laser treatment (wavelength, 905 nm ; frequency, 256 Hz ; irradiation time, 50 sec ; pulse duration, 100 nsec ; distance, 3 cm ; peak irradiance, 50 W/cm2 in irradiated area ; and total exposure, 0.41 mJ/cm2) induced further shortening of latencies, suggesting its stimulatory influence on pain perception. Administration of morphine (20 mg/kg) prolonged the latency of response to the hot plate in both sham- and laser-irradiated mice. This prolongation tended to be lesser in laser- irradiated animals. Further investigations are required to elucidate the mechanism of the observed effect of laser.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA