Pregled bibliografske jedinice broj: 197679
Dihydrogenated ergot compounds bind with high affinity to GABA-A receptor-associated Cl ionophore
Dihydrogenated ergot compounds bind with high affinity to GABA-A receptor-associated Cl ionophore // European journal of pharmacology, 202 (1991), 1; 109-111 doi:10.1016/0014-2999(91)90262-O (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 197679 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dihydrogenated ergot compounds bind with high affinity to GABA-A receptor-associated Cl ionophore
Autori
Tvrdeić, Ante ; Peričić, Danka
Izvornik
European journal of pharmacology (0014-2999) 202
(1991), 1;
109-111
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
ergot alkaloids ; [3H]TBOB binding ; mouse brain
Sažetak
The binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes of the mouse brain (cerebrum minus cortex) in the presence of dihydroergotoxine, dihydroergosine, dihydroergotamine and gamma-aminobutyric acid (GABA) was studied in vitro. [3H]TBOB binding was inhibited by all drugs used. The rank order of potency was dihydroergotoxine greater than GABA greater than dihydroergosine greater than dihydroergotamine. This suggests that dihydrogenated ergot compounds, especially dihydroergotoxine, possess appreciable binding activity (comparable to that of benzodiazepines and barbiturates) at the GABAA receptor-associated C1- ionophore.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Excerpta Medica
- Index Medicus
