Naslov
The effect of cortisol and 11-epi-cortisol on DNA and RNA synthesis in isolated cells of human ACTH-secreting pituitary tumours

Autori
Rešetić, Josip ; Lüdecke, D ; Rižnar, Vesna ; Mildner, Boris ; Petek, Marijan ; Sekso, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biological Chemistry Hoppe-Seyler ; 17th FEBS Meeting / Decker, K. ; Stoffel, W. ; Zachau, H. G. - Berlin : New York : Walter de Gruyter, 1986, 269-269

Skup
17th FEBS Meeting, Berlin

Mjesto i datum
Berlin, Njemačka, 24.08.1986. - 29.08.1986

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ACTH-secreting pituitary adenoma; DNA and RNA synthesis; cortisol

Sažetak
DNA and RNA de novo synthesis with implanted radioactive nucleotides (3H-thymidine in DNA and 3H-uridine in RNA) was studied in isolated ACTH-secreting pituitary adenoma (1) and tumors (4). The percentage of radioactivity found in DNA and RNA ranges between 4 and 22% under basal conditions. Cortisol tends to decrease the basal RNA synthesis (97% N=2 and 90% N03 ; basal=100%) while its effect on the DNA synthesis is distintly suppressive (62% N=5). 11-epi-cortisol supress the basal RNA synthesis (88% N=2) but it has a stimulating effect on DNA synthesis (118% N=2), so that no supression of DNA synthesis takes place when it is combined with cortisol.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

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