Naslov
Modulation of in vitro growth of murine myeloid leukemia by an autologous substance immunochemically cross-reactive with insulin and antiinsulin serum
(MODULATION OF INVITRO GROWTH OF MURINE MYELOID-LEUKEMIA BY AN AUTOLOGOUS SUBSTANCE IMMUNOCHEMICALLY CROSS-REACTIVE WITH INSULIN AND ANTIINSULIN SERUM)

Autori
Vuk-Pavlović, Zvezdana ; Pavelić, Krešimir ; Vuk-Pavlović, Stanimir

Izvornik
Blood (0006-4971) 67 (1986), 4; 1031-1035

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
in vitro ; murine myeloid leukemia ; immunochemically ; cross-reactive ; antiinsulin serum

Sažetak
Murine myeloid leukemia secretes a substance immunochemically cross- reactive with insulin (SICRI) both in vivo and in serum-free media. High SICRI concentrations in peripheral blood of tumorous animals do not affect circulating glucose levels. In culture, DNA synthesis rate per leukemic cell is proportional to cell density and is reduced by antiinsulin serum. Culture medium conditioned by leukemia cells as well as SICRI affinity purified from this medium stimulate DNA synthesis in cultured leukemia cells. It appears that autocrine stimulation of murine myeloid leukemia can be mediated in part by an insulin-related growth factor.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA