Naslov
6-deoxy-6-bromo-ascorbic acid inhibits growth of mouse melanoma cells

Autori
Osmak, Maja ; Eckert-Maksić, Mirjana ; Pavelić, Krešimir ; Maksić, Zvonimir B. ; Spaventi, Radan ; Beketić, Lidija ; Kovaček, Ivančica ; Šušković, Božidar

Izvornik
Research in experimental medicine (0300-9130) 190 (1990), 1; 443-449

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
proliferative capacity ; mouse melanoma cell ; L929 fibroblast ; potential antitumor agent ; grow cell population

Sažetak
The influence of 6-deoxy-6-bromo-ascorbic acid (6-Br-AA) and ascorbic acid (AA) on the growth of mouse melanoma cell line b16, mouse fibroblasts (L929), and human cervical carcinoma HeLa cells was examined by in vitro experiments. 6-Br-AA was added in concentrations 10−1 to 10−8 M and for incubation periods of 2, 18, 24 and 72h. The present results indicate that 6-Br-AA exhibits a highly pronounced inhibiting effect on growth and DNA synthesis of melanoma cells. Inhibitory effect of 6-Br-AA was confirmed by the in vivo experiments. The tumor-suppressing effect on solid melanoma B16 was attained with 9 mg per mouse given three times daily for 16 days. Our preliminary results indicate that 6-Br-AA could serve as a potential antitumor agent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA