Naslov
Buthyrylcholinesterase activity and plasma lipids in dexamethasone treated rats

Autori
Lucić Vrdoljak, Ana ; Bradamante, Vlasta ; Radić, Božica ; Peraica, Maja ; Fuchs, Radovan ; Reiner, Željko

Izvornik
Acta pharmaceutica (1330-0075) 55 (2005); 177-185

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dexamethasone; butyrylcholinesterase; liver; white adipose tissue; protein synthesis; lipids; lipoproteins

Sažetak
This paper describes effect of glucocorticoide dexamethasone (DM) given intraperitoneally on the catalytic activity of buthyrylcholinesterase (BuChE) measured in plasma, liver and white adipose tissue of rats of both sexes. The effects of DM on the concentration of plasma lipids and lipoproteins were also tested. The rats were given multiple (2 and 4) pharmacological doses (0.4 and 3.0 mg kg-1 body mass) of DM. All animals were sacrificed 48 hours after the last dosing. The administration of DM significantly decreased the catalytic activity of BuChE in plasma and liver of all treated groups regardless of the sex. BuChE catalytic activity in white adipose tissue differed depending on dose and frequency of administration. In contrast to liver where both doses caused significant BuChE inhibition, in adipose tissue the lower DM dose did not inhibit BuChE activity, and the inhibition achieved by the higher dose was not as strong as in liver. This result corroborates an earlier hypothesis that BuChE is also synthesized in the adipose tissue. DM significantly increased plasma concentrations of triglycerides, total cholesterol and high-density lipoprotein (HDL) cholesterol and decreased low-density lipoprotein (LDL) cholesterol concentration. There was neither positive correlation between BuChE and triglycerides nor negative correlation between BuChE and HDL. Changes in lipid profile during DM treatment were not sex- and time-dependent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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