Naslov
Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: correlations with degree of dysplasia

Autori
Pavelić, Zlatko ; Pavelić, Ljiljana ; Pavelić, Krešimir ; Genta R.M. ; Ray, M.B. ; Dvornik, G. ; Šćukanec-Špoljar, Mira ; Peacock, J.S.

Izvornik
Anticancer research (0250-7005) 11 (1991), 5; 1671-1676

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
expression ; carcinoembryonic antigen ; ulcerative colitis ; tubular adenomas ; hyperplastic polyps

Sažetak
Sections of tubular adenomas (n = 40), ulcertive colitis (n = 97) and hyperplastic polyps (n = 31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scattered weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA