Naslov
Binding of human growth hormone to plasma growth hormone-binding protein in acomegalic patients before and after adenoectomy

Autori
Furač, Ivana ; Mildner, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
HB 93 ; Godišnji sastanak hrvatskih biokemičara / Flögel, Mirna - Zagreb : Hrvatsko biokemijsko društvo, 1993, 147-147

Skup
HB93 ; Godišnjisastanak hrvatskih biokemičara

Mjesto i datum
Zagreb, Hrvatska, 17.06.1993. - 18.06.1993

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
human growth hormone; growth hormone binding protein; acromegaly; hypophysoectomy

Sažetak
In plasma, hGH immunoreactivity is present in several molecular weight complexes. Besides oligomeric complexes composed of structurally diverse GH monomers, GH monomers also bind to a specific GH-binding protein. Binding of 125I-GH to GHBP from plasma controlpool was time, temperature and concentration dependent and it was specific to hGH. GHBP from plasma of 6 acromegalic patients before the operation showed almost the same affinity of 125I-GH binding as GHBP from plasma control pool (Ka=2.53xE8 M-1 vs. Ka=1.47xE8 M-1). One hour after the operation, detectable hGH immunoreactivities in plasma were significantly lower and the GH binding to GHBP almost disappeared. It was concluded that GHBP exists in plasma as long as there is pituitary GH secretion. When there is no secretion, GH as well as GHBP are cleared from plasma.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Kliničke medicinske znanosti

Napomena
Rad je financiran projektom 3-01-211 Ministarstva znanosti i tehnologije, RH.

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