Naslov
In vitro effects of TRH and AVP with and without cortisole on hormone secretion and DNA/RNA synthesis from cell culture of clinically nonfunctioning pituitary adenomas

Autori
Rešetić, Josip ; Krpan, Ružica ; Mildner, Boris ; Gnjidić, Živko ; Vizner, Branka ; Sekso, Mladen ; Vilibić, Tanja ; Petek, Marijan ; Rižnar, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
HB 93, Godišnji sastanak hrvatskih biokemičara / Flögel, Mirna - Zagreb : Hrvatsko biokemijsko društvo, 1993, 152-152

Skup
HB 93, Godišnji sastanak hrvatskih biokemičara

Mjesto i datum
Zagreb, Hrvatska, 17.06.1993. - 18.06.1993

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
nonfunctionin pituitary adenomas; hormone secretion; DNA/RNA synthesis

Sažetak
This study was performed to compare effect of TRH and AVP on DNA/RNA synthesis and hormone release (GH, ACTH, PRL, aplpha-TSH, LH, FSH) on pituitary "nonsecreting" adenomas in vitro. The cells from two clinicaly nonfunctioning tumors and one pluryhormonal tumor from patient with acromegaly symptoms was cultured on ECM surface. The DNA/RNA synthesis and hormone secretion were specific for every tumor, so we could find a difference in both clinically nonsecreting tumors in basal state or under TRH, AVP or cortisol activity. On the basis of these findings we could describe the tumors as partially hormone active, which can not be distinguished in vivo, where we in those cases measured hormones parallel secreted from pituitary.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Kliničke medicinske znanosti

Napomena
Rad je financiran projektom 3-01-211, Ministarstva znanosti i tehnologije, RH

POVEZANOST RADA