Pregled bibliografske jedinice broj: 196563
Electrochemical oxidation of azithromycin and its derivatives
Electrochemical oxidation of azithromycin and its derivatives // Journal of pharmaceutical and biomedical analysis, 33 (2003), 4; 647-654 doi:0.1016/S0731-7085(03)00315-7 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 196563 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Electrochemical oxidation of azithromycin and its
derivatives
Autori
Mandić, Zoran ; Weitner, Zlatko ; Ilijaš, Marina
Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 33
(2003), 4;
647-654
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
azithromycin ; erythromycin ; anodic oxidation ; cyclic voltammetry ; electrochemical studies
Sažetak
The electrochemical oxidation of azithromycin was investigated in order to elucidate the mechanism for possible oxidative metabolic pathways in humans. Electrochemical studies were carried out by cyclic voltammetry and preparative scale electrolysis at glassy carbon electrodes. It was found that azithromycin undergoes anodic oxidation at one or both amine groups with the rapid follow-up chemistry of intermediate radical cation. Main products of the oxidation were determined by HPLC analysis and were identified as a protonated azithromycin and products obtained by demethylation of the 3´- dimethylamino or macrolactone amino group.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo
POVEZANOST RADA
Ustanove:
Pliva-Istraživački institut
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts
