Naslov
Evidence for a role of EGF receptor in the progression of human lung carcinoma

Autori
Pavelić, Krešimir ; Banjac, Željka ; Pavelić, Jasminka ; Spaventi, Šime

Izvornik
Anticancer research (0250-7005) 13 (1993), 4; 1133-1138

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
EGF receptor ; human lung carcinoma

Sažetak
Sixty-three primary lung carcinomas were examined immunohistochemically for the presence of epidermal growth factor receptors (EGF-R). Of these tumors 35 (55.5 %) were positive for EGF-R. A positive correlation between overexpression of EGF-R, on the one hand, and high metastatic rate, poor tumor differentation and high rate of tumor proliferation, on the other hand, was found. From one tumor with an extremely high amount of EGF-R a primary cell culture was established. The addition of anti-EGF-R serum to this culture decreased cell proliferation. Our results support the evidence for a positive relationship between overexpression of EGF-R and invasiveness, poor differentiation and high growth rate of tumor cells. The blockade of EGF-R with specific antibodies suppressed tumor cell-proliferation, suggesting a role of EGF-R in tumor progression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA