╨╧рб▒с>■  58■   6                                                                                                                                                                                                                                                                                                                                                                                                                                                ье┴G ┐┼ bjbjО┘О┘ ь│ь│┼      ]ЪЪЪЪЪЪЪооооо ║ оЄ╥╥╥╥╥╥╥╥╝╛╛╛╛╛╛$їЇщlт!Ъ╥╥╥╥╥тцЪЪ╥╥╥ццц╥ Ъ╥Ъ╥╝ооЪЪЪЪ╥╝ц╓ц╝ЪЪ╝╥╞ ░╗ l┼оо▄ ╝Title A single-stage mechanism controls cellular aging: the role of Sudden Senescence Syndrome Ivica Rubelj*, Miljenko Huzak(, Branko Brdar*, Marina Ferenac*, Milena Ivankovi* *Department of Molecular Genetics, Ruer Boakovi Institute, Bijeni ka 54, Zagreb 10000, Croatia; (Department of Mathematics, University of Zagreb, Bijeni ka 30, Zagreb 10000, Croatia, rubelj@rudjer.irb.hr Abstract It has been well established that various mammalian cells demonstrate a limited growth capacity in culture referred to as cellular or replicative senescence. There is also some evidence in support of the idea that this is the basis for organismal aging. Recent studies have revealed the molecular mechanisms of telomere biology and the involvement of this in not only cell senescence but also cell cycle control, genome stability and immortalization. This has provided an explanation of various phenomena related to aging and carcinogenesis that was previously unresolved. In this presentation I will describe some of the most important features of normal cell aging and the processes that result in malignant transformation, in the context of several molecular models that have been proposed to explain these phenomena. └┬┌№■ln02 ┼ ∙ЎЄьЄуЄ▄╓╠╓─Ў─B*CJhnH  j╫Ё5Б6БCJH* 5Б6БCJ 5Б6БCJH* j╫Ё5БCJH* 5Б>*CJ5БCJCJ 5БCJmH  └┬jl   ┼ №№··ўўўїїєїтДTД╨dV ╞к0 ╢>АББА$$  └┬jl   ┼ ¤¤¤¤√√√°їT ░╨/ ░р=!░"░#Ра$Ра%░ [$@ё $NormalmH :`: Heading 1$@&B*CJhnH <A@Є б<Default Paragraph Font:P`Є: Body Text 2$ 5БCJmH,J`,Subtitle5БCJ(U`в( Hyperlink>*B*8V@в!8FollowedHyperlink>*B* ┼    ┼ ┼ ┼ ╟╟   Ivica RubeljMC:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\II European Workshop.doc Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj@C:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\Opatija.doc Administrator$E:\RUBELJ\Rubelj-Mat. Biol. 2004.doc @А──xЕL──┼pp@GРЗzА Times New Roman5РАSymbol3&Р ЗzА Arial;РАMath3Mono"1И╨h╨BЦf╨BЦf░ю!е└┤┤А0d╙  Abstract Ivica Rubelj Administrator■ рЕЯЄ∙OhлС+'│┘0hИРд░╚╘ф № $ 0 <HPX`ф Abstract bst Ivica RubeljovicNormaluAdministratoro2miMicrosoft Word 8.0@F├#@Гп l┼@Гп l┼░ю■ ╒═╒Ь.УЧ+,∙оD╒═╒Ь.УЧ+,∙о4Ё hp|ДМФ Ьдм┤ ╝ ╤фIRB╙│   Abstract TitleШ 6> _PID_GUIDфAN{CE8362A9-8D86-11D5-89AB-00E0291B800E} ■    ■   ■    !"■   ¤   %■   ■   ■                                                                                                                                                                                                                                                                                                                                                                   Root Entry         └F║ы║ l┼pa0╗ l┼'А1Table         WordDocument        SummaryInformation(    DocumentSummaryInformation8            CompObj            j                        ■                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ■       └FMicrosoft Word Document MSWordDocWord.Document.8Ї9▓q■ рЕЯЄ∙OhлС+'│┘0hИРд░╚╘ф № $ 0 <HPX`ф Abstract bst Ivica RubeljovicNormaluAdministratoro3miMicrosoft Word 8.0@╥Ik@Гп l┼@Ф ў l┼ЮЕ■ ╒═╒Ь.УЧ+,∙оD╒═╒Ь.УЧ+,∙о4Ё hp|ДМФ Ьдм┤ ╝ ╤фIRBR│   Abstract TitleШ 6> _PID_GUIDфAN{CE8362A9-8D86-11D5-89AB-00E0291B800E}└┬┌№■ln02 ┼ К ∙ЎЄьЄуЄ▄╓╠╓─Ў─∙Ў╓B*CJhnH  j╫Ё5Б6БCJH* 5Б6БCJ 5Б6БCJH* j╫Ё5БCJH* 5Б>*CJ5БCJCJ 5БCJmH  └┬jl   ┼ ИК№№··ўўўїїєїт№№ДTД╨dV ╞к0 ╢>АББА$$░╨/ ░р=!░"░#Ра$Ра%░Cell Biology and Mathematical Modelling, Hvar, 2004. Abrupt Telomere Shortening as a Model for Stochastic cell aging; [$@ё $NormalmH :`: Heading 1$@&B*CJhnH <A@Є б<Default Paragraph Font:P`Є: Body Text 2$ 5БCJmH,J`,Subtitle5БCJ(U`в( Hyperlink>*B*8V@в!8FollowedHyperlink>*B* E    56<=}~НОGШААШААШААЮААШААЮААШААЮААШААЮАА К┼   Unknown Administrator Ivica RubeljMiljenko Huzak Olivia Smith,Laboratorij za eksperimentalnu kancerologiju-Laboratorij za molekularnu genetiku eukariotaGG   Ivica RubeljMC:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\II European Workshop.doc Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj@C:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\Opatija.doc Administrator$E:\RUBELJ\Rubelj-Mat. Biol. 2004.doc @АююxЕLюэм'456=|~КОэюАDEqqlpЖpИpqКp╛q┬╝pdqnqp▄p@pИ@GРЗzА Times New Roman5РАSymbol3&Р ЗzА Arial;РАMath3Mono"1И╨h╨BЦf╥BЦfЮЕ!е└┤┤А0dR  Abstract Ivica Rubelj Administratorье┴G ┐┼ bjbjО┘О┘ ь│ь│E      ]ЪЪЪЪЪЪоОООО Ъ онЄьььььььь╓╪╪╪╪╪╪$Я ЇУ l№▒Ъььььь№ЪЪьь▓:ь ЪьЪь╓ооЪЪЪЪь╓╓╓ЪЪ╓ьж ░б} l┼орОЎ ╓Root Entry         └F║ы║ l┼░б} l┼:@1Table     WordDocument        3SummaryInformation(     Ш        *        ,     ■                                                                                               + ■                           47¤   ■   ■   ;9<=>?@A■                                                                                                                                                                                                                                                           DocumentSummaryInformation8            ╠CompObj            j0Table                          ■    ■    ■    !"#$%&'()*+,-./0123456789:;<=>?@■                                                                                                                                                                                                                                                               8362A9-8D86-11D5-89AB-00E0291B800E}■ рЕЯЄ∙OhлС+'│┘0hИРд░╚╘ф № $ 0 <HPX`ф Abstract bst Ivica RubeljovicNormaluAdministratoro3miMicrosoft Word 8.0@╥Ik@Гп l┼@Ф ў l┼■       └FMicrosoft Word Document MSWordDocWord.Document.8Ї9▓q■ ╒═╒Ь.УЧ+,∙оD╒═╒Ь.УЧ+,∙о4Ё hp|ДМФ Ьдм┤ ╝ ╤фIRBR│   Abstract TitleШ 6> _PID_GUIDфAN{CEЮЕ [$@ё $NormalmH :`: Heading 1$@&B*CJhnH <A@Є б<Default Paragraph Font:P`Є: Body Text 2$ 5БCJmH,J`,Subtitle5БCJ(U`в( Hyperlink>*B*8V@в!8FollowedHyperlink>*B* E    56<=}~НОGШААШААШААЮААШААЮААШААЮААШААЮАА К┼   Unknown Administrator Ivica RubeljMiljenko Huzak Olivia Smith,Laboratorij za eksperimentalnu kancerologiju-Laboratorij za molekularnu genetiku eukariotaGG   Ivica RubeljMC:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\II European Workshop.doc Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj5C:\TEMP\AutoRecovery save of II European Workshop.asd Ivica Rubelj@C:\WINNT\Profiles\Administrator\Desktop\RUBELJ\Pisma\Opatija.doc Administrator$E:\RUBELJ\Rubelj-Mat. Biol. 2004.doc @АююxЕLюэм'456=|~КОэюАDEqqlpЖpИpqКp╛q┬╝pdqnqp▄p@pИ@GРЗzА Times New Roman5РАSymbol3&Р ЗzА Arial;РАMath3Mono"1И╨h╨BЦf╥BЦfЮЕ!е└┤┤А0dR  Abstract Ivica Rubelj Administrator