Naslov
Abrupt Telomere Shortening as a Model for Stochastic cell aging

Autori
Rubelj, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Cell Biology and Mathematical Modelling

Mjesto i datum
Hvar, Hrvatska, 07.06.2004. - 18.06.2004

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Stochastic cell aging; Abrupt telomere shortening

Sažetak
It has been well established that various mammalian cells demonstrate a limited growth capacity in culture referred to as cellular or replicative senescence. There is also some evidence in support of the idea that this is the basis for organismal aging. Recent studies have revealed the molecular mechanisms of telomere biology and the involvement of this in not only cell senescence but also cell cycle control, genome stability and immortalization. This has provided an explanation of various phenomena related to aging and carcinogenesis that was previously unresolved. In this presentation I will describe some of the most important features of normal cell aging and the processes that result in malignant transformation, in the context of several molecular models that have been proposed to explain these phenomena.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA