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Pregled bibliografske jedinice broj: 196227

Macrolide Non-Steroidal Antiinflammatory drug conjugates

Marković, Stribor; Mesić, Milan; Tomašković, Linda; Komac, Marijana; Makaruha Stegić, Oresta; Poljak, Višnja; Selmani, Selvira; Šijan, Gordana; Hrvačić, Boška; Merćep, Mladen
Macrolide Non-Steroidal Antiinflammatory drug conjugates // Knjiga sažetaka / Book of Abstracts Zagreb: Kemija u industriji / Škare, Danko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2005. str. 79-79 (predavanje, nije recenziran, sažetak, znanstveni)

CROSBI ID: 196227 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Macrolide Non-Steroidal Antiinflammatory drug conjugates

Autori
Marković, Stribor ; Mesić, Milan ; Tomašković, Linda ; Komac, Marijana ; Makaruha Stegić, Oresta ; Poljak, Višnja ; Selmani, Selvira ; Šijan, Gordana ; Hrvačić, Boška ; Merćep, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / Book of Abstracts Zagreb: Kemija u industriji / Škare, Danko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2005, 79-79

Skup
XIX. skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
makrolidi; nesteroidni protuupalni lijekovi; prostaglandini; leukotrieni
(macrolides; NSAID; non-steroidal anti-inflammatory drugs; prostaglandins; leukotrienes)

Sažetak
Non steroidal anti-inflammatory drugs (NSAIDs) have a long clinical use for treatment of various inflammatory diseases like rheumatoid arthritis. However, these drugs are not devoid of serious side effects affecting gastrointestinal and cardiovascular systems. Chemical research of NSAIDs begun in the mid XIX century, with the discovery of salycilic acid derivatives from natural resources, and culminated with the discovery of acethyl salycilic acid over a century ago in Bayer. Since then, many molecules have been designed inspired with the efficacy of "Aspirin" . It took 70 years to discover that NSAIDs inhibit prostaglandin synthesis, and 80 years to isolate the key enzymes that control prostaglandin synthesis, cyclooxygenase I and cyclooxygenase II. Cyclooxygenase I was described as "constitutive" controling normal homeostasis, and cyclooxygenase II as "inflammatory" , involved in ptahological processes in organism. However, new class of cyclooxygenase II specific inhibitors ended, after several years of worlwide use, in withdrawal from market due to increased risk of cardiovascular side effects. The 150 years of research thus was forced to change direction. We generated a new class of compounds, 14 and 15 member ring macrolides, with promising in vitro and in vivo anti-inflammatory activites.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Ustanove:
Pliva-Istraživački institut

Profili:

Avatar Url Linda Tomašković (autor)

Avatar Url Mladen Merćep (autor)

Avatar Url Boška Hrvačić (autor)

Avatar Url Milan Mesić (autor)

Citiraj ovu publikaciju:

Marković, Stribor; Mesić, Milan; Tomašković, Linda; Komac, Marijana; Makaruha Stegić, Oresta; Poljak, Višnja; Selmani, Selvira; Šijan, Gordana; Hrvačić, Boška; Merćep, Mladen
Macrolide Non-Steroidal Antiinflammatory drug conjugates // Knjiga sažetaka / Book of Abstracts Zagreb: Kemija u industriji / Škare, Danko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2005. str. 79-79 (predavanje, nije recenziran, sažetak, znanstveni)
Marković, S., Mesić, M., Tomašković, L., Komac, M., Makaruha Stegić, O., Poljak, V., Selmani, S., Šijan, G., Hrvačić, B. & Merćep, M. (2005) Macrolide Non-Steroidal Antiinflammatory drug conjugates. U: Škare, D. (ur.)Knjiga sažetaka / Book of Abstracts Zagreb: Kemija u industriji.
@article{article, author = {Markovi\'{c}, Stribor and Mesi\'{c}, Milan and Toma\v{s}kovi\'{c}, Linda and Komac, Marijana and Makaruha Stegi\'{c}, Oresta and Poljak, Vi\v{s}nja and Selmani, Selvira and \v{S}ijan, Gordana and Hrva\v{c}i\'{c}, Bo\v{s}ka and Mer\'{c}ep, Mladen}, editor = {\v{S}kare, D.}, year = {2005}, pages = {79-79}, keywords = {makrolidi, nesteroidni protuupalni lijekovi, prostaglandini, leukotrieni}, title = {Macrolide Non-Steroidal Antiinflammatory drug conjugates}, keyword = {makrolidi, nesteroidni protuupalni lijekovi, prostaglandini, leukotrieni}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Opatija, Hrvatska} }
@article{article, author = {Markovi\'{c}, Stribor and Mesi\'{c}, Milan and Toma\v{s}kovi\'{c}, Linda and Komac, Marijana and Makaruha Stegi\'{c}, Oresta and Poljak, Vi\v{s}nja and Selmani, Selvira and \v{S}ijan, Gordana and Hrva\v{c}i\'{c}, Bo\v{s}ka and Mer\'{c}ep, Mladen}, editor = {\v{S}kare, D.}, year = {2005}, pages = {79-79}, keywords = {macrolides, NSAID, non-steroidal anti-inflammatory drugs, prostaglandins, leukotrienes}, title = {Macrolide Non-Steroidal Antiinflammatory drug conjugates}, keyword = {macrolides, NSAID, non-steroidal anti-inflammatory drugs, prostaglandins, leukotrienes}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Opatija, Hrvatska} }

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