Naslov
New compounds, compositions and methods for treatment of inflammatory diseases and conditions

Autori
Merćep, Mladen ; Mesić, Milan ; Tomašković, Linda ; Marković, Stribor ; Makaruha, Oresta ; Poljak, Višnja

Broj patenta
WO 2004/005310 A2

Godina
2002

Datum patenta
15.01.2004.

Nositelj prava
Pliva d.d., Zagreb, Hrvatska

Sažetak
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, S represents a steroid subunit (steroid moiety) derived from steroid drug with anti-inflammatory activity and L represents a linker molecule linking M and S, (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals. Such compounds inhibit many cytokines and immune mediators involved in immune responses which cause inflammation, allergy, or alloimmunity, including without limitation IL-1, 2, 4, 5, 6, 10, 12, GMCSF, ICAM, and TNF-α . Importantly, anti-inflammatory steroids exert a direct anti-inflammatory effect through binding to the glucocorticosteroid receptor.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA