Naslov
High c-erbB-2 protein level in colorectal adenocarcinomas correlates with clinical parameters

Autori
Kapitanović, Sanja ; Spaventi, Radan ; Poljak, Ljiljana ; Kapitanović, Milan ; Pavelić, Zlatko ; Gluckman, J.L. ; Spaventi, Šime ; Pavelić, Krešimir

Izvornik
Cancer detection and prevention (0361-090X) 18 (1994), 2; 97-101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
erbB-2; colorectal cancer

Sažetak
Sections of normal colon, adenomas, and adenocarcinomas were examined by immunohistochemistry for the expression of c-erbB-2 proto-oncogene product in order to assess its potential diagnostic value in predicting the malignant potential of these lesions. We compared the degree of epithelial abnormality and clinical parameters, including Dukes' classification and survival time with the extent of immunoperoxidase staining. Sections of normal colon and tubular adenomas examined demonstrated a weak immunostaining localized to the luminal surface cells. However, higher level of c-erbB-2 expression was observed in dysplastic areas of one tubular and one villous adenoma. Out of 40 adenocarcinomas, only 2 samples showed weak immunoreaction, while 38 samples were moderately or strongly positive for c-erbB-2 protein. The intensity of staining correlated positively with the stage of disease and postoperative survival time.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA