Naslov
Modifikacije 1-tiadibenzo[e, h]azulena u položaju 8: sinteza i protuupalno djelovanje
(Modifications of 1-thia-dibenzo[e, h]azulenes at position 8: synthesis and antiinflammatory activity thereof)

Autori
Ozimec Landek, Ivana ; Mesić, Milan ; Pešić, Dijana ; Stanić, Barbara ; Hrvačić, Boška ; Merćep, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
XIX. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
1-thia-dibenzo[e; h]azulenes; anti-inflammatory activity; modification

Sažetak
1-Thia-dibenzo[e, h]azulene derivatives, depicted below by general formula, were found to be new potent molecules with anti-inflammatory activity. One of the main research goals was to investigate the way modifications of different sites at 1-thia-dibenzo[e, h]azulene scaffold affect biological activity. The most obvious and synthetically very interesting modification appeared to be exchange of different heteroatoms (O, S and N) and CH2 group at position 8. Synthetic routes for 8-oxa-, 8-thia-, 8-aza- and 8H-1-thia-dibenzo[e, h]azulene derivatives, respectively, will be presented. In vitro and in vivo data revealed significant differences in anti-inflammatory activity of aforementioned analogues.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA