Naslov
No association of CCR5D32 gene mutation with multiple sclerosis in Croatian and Slovenian patients

Autori
Ristić, Smiljana ; Lovrečić, Luca ; Brajenović-Milić, Bojana ; Starčević-Čizmarević, Nada ; Šega Jazbec, Saša ; Barac-Latas, Vesna ; Vejnović, Danilo ; Sepčić, Juraj ; Kapović, Miljenko ; Peterlin, Borut

Izvornik
Multiple sclerosis (1352-4585) 12 (2006), 3; 360-362

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
multiple sclerosis; CCR5 polymorphism; susceptibility gene

Sažetak
Several studies investigating the role of the CCR5D32 mutation in multiple sclerosis (MS) have reported varied, often contradictory results. Therefore in the present study we have analysed whether the CCR5D32 mutation is associated with the risk of/or disease process in Croatian and Slovene MS patients. 325 MS patients and 356 healthy controls were genotyped by polymerase chain reaction method. Our results showed no significant differences in the distribution of CCR5D32 mutations between MS and control subjects indicating that this mutation does not influence susceptibility to MS. Furthermore, we did not observe that CCR5D32 carrier-status could modulate age of disease onset or progression of the disease. It is therefore our conclusion that the present study indicates that the CCR5D32 mutation is neither protective of, nor a risk factor for MS development.

Izvorni jezik
Engleski

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