Naslov
Molecular approaches to inhibit oncogenesis by RNA tumor viruses

Autori
Chandra, Prakash ; Ebener, Uwe ; Steel, Linda, K. ; Laube, Horst ; Gericke, Dieter ; Mildner, Boris ; Bardos, T.J. ; Ho, Y. K. ; Goetz, Angelika

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Annals of the New York Academy of Sciencies, Vol. 284 / - New York (NY) : New York Academy of Sciences, 1977, 444-462

Skup
Antiviral agents and tumor viruses

Mjesto i datum
Sjedinjene Američke Države, 01.03.1977. - 04.03.1977

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
RNA tumor viruses; inhibitors; oncogenesis

Sažetak
Efforts to develop compounds that inhibit viral DNA polymerases by interacting with templates may lead to the discovery of useful compounds exibiting a higher therapeutic index, i.e. a low cytotoxicity and a high antiviral activity. This approach, however, will not lead to the development of a specific inhibitor of the viral enzyme unless one finds a compound that binds specifically to 70 S RNA. The strategical approach to develop an inhibitor of this type is, at the present state of our knowledge, unthinkable. The second molecular approach, which has proved to be more useful and relatively specific in developing such inhibitors, is to design compounds that bind to the viral enzyme. One of these compounds is the polycytidylic acid containing 5-mercapto-substituted cytidylate units. The mode of action of this compound as an inhibitor of the viral DNA polymerase, and its biological implications are presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA