Naslov
Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure

Autori
Kokić, Slaven ; Buković, Damir ; Radman, Maja ; Čapkun, Vesna ; Gabrić, Nikica ; Lesko, Vesna ; Karelović, Deni ; Stančerić, Tajana

Izvornik
Collegium antropologicum (0350-6134) 27 (2003); 181-187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Lispro insulin ; Metformin ; Niddm ; Antidiabetic drug

Sažetak
The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed -time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA(1c) was measured by ion exchange chromatography. HbA(1c) significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA(1c) in comparison with the above mentioned more traditional approaches.

Izvorni jezik
Engleski

POVEZANOST RADA