Pregled bibliografske jedinice broj: 193607
Apoptosis of pancreatic B-cells in alloxan treated rats
Apoptosis of pancreatic B-cells in alloxan treated rats // Toxicology Letters
Alicante, 1996. str. 106-106 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Apoptosis of pancreatic B-cells in alloxan treated rats
Autori
Veljača, Marija ; Glojnarić, Ines ; Ševeljević-Jaran, Daša ; Krnić, Žarka ; Brajša, Karmen ; Ferenčić, Željko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Toxicology Letters
/ - Alicante, 1996, 106-106
Skup
EUROTOX 1996
Mjesto i datum
Alicante, Španjolska, 22.09.1996. - 25.09.1996
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
apoptosis; B-cell and alloxan
Sažetak
The alloxan toxicity concept has been based on its rapid and selective uptake by islet B-cells and their high sensitivity to alloxan formed peroxides. Since reaktive oxigen metabolites have been demonstrate to cause apoptotic cell death, the aim of this study was to investigate weather alloxan causes morphological picture of apoptosis rather than previously described necrosis. 48 hours after single sc. administration of 150 mg/kg of alloxan monohydrate, female Wistar rats developed severe hyperglicemia as well as B-cell loss. Histological analysis has demonstrated apoptosis, not necrosis, of B-cells in alloxan treated animals. No apoptotic cells were found in non treated aimals.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Napomena
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