Naslov
Erythromycin inhibits LPS induced inflammation in rats

Autori
Rusić-Pavletić, Jasna ; Brajša, Karmen ; Glojnarić, Ines ; Čulić, Ognjen ; Dominis-Kramarić, Miroslava ; Marković, Darko ; Bencetić, Vlatka ; Šunjić, Ivan ; Eraković, Vesna ; Danhoff Meinrat, Parnham Michael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book / ? - Sevilla, 2000, 94-94

Skup
ICMAS KO5

Mjesto i datum
Sevilla, Španjolska, 26.01.2000. - 28.01.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
LPS; inflammation; macrolide antibiotics

Sažetak
Macrolides have been reported to reduce phagocytosis, neutrophil chemotaxis, and the relise of proinflammatory cytokines (Il-1 and TNFa). An animal model was designet to evaluate the effect of erythromycin (Ery) in rats upon LPS induced inflammation. Cytokines, IL-6 and IFN gamma and acute phase proteins, CRP, alpha2 macroglobulin and albumins were chosen as markers and monitored 48 hours. A 3.2 mg/kg dose of LPS resulted in pronouced inflammatory symptoms and was used in the following experiments. Animals treated with Ery showed 2-fold lower concentrations of IL-6 and IFN gamma. Albumins, CRP and alpha 2 macroglobuline were decreased.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
NEPOTPUN BIBLIOGRAFSKI ZAPIS!!

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