Naslov
The development of PL 14736 for treatment of inflammatory bowel disease

Autori
Veljača, Marija ; Krnić, Žarka ; Brajša, Karmen ; Pavić-Sladoljev, Dubravka ; Mildner, Boris ; Ševeljević-Jaran, Daša ; Kolega, Marko ; Erceg, Damir ; Krznarić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book of the 3rd Congress of the Croatian Society of gastroenterology / - Zagreb, 2001, 9-9

Skup
Congress of the Croatian Society of gastroenterology (3 ; 2001)

Mjesto i datum
Zagreb, Hrvatska, 23.09.2001. - 26.09.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
IBD; peptide non-clinical safety

Sažetak
Pl 14736 is a 15 amino acid peptide of a unique sequence, a part of a larger molecule. Pharmacological activity of PL 14 736 has been tested in vitro and in vivo, revealing beneficial activity against experimental tissue damage. Since PL 14736 has shown potent protective and healing properties in the models of upper gastrointestinal tract lesions and in particular in acute and sub-acute models of colitis, this compound was taken to pursue pre-clinical development for IBD indication. In order to fulfill regulatory requirements for the conduct of the phase I study, all non-clinical safety studies were performed with PL 14736.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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